Effect of salt loading on renal hemodynamics and electrolytes excretion in essential hypertension and in chronic glomerulonephritis.

In 1905, Ambard and Beaujard1) found that the administration of NaCl to the patients with hypertension produced a further increase in blood pressure and the restriction of salt resulted in a fall of blood pressure in these patients. Since then, many studies have been attempted to in vestigate the participation of sodium chloride in the occurrence of hyper tension. Dahl2) investigated the daily salt intake in 1300 subjects and found the high incidence of hypertension in the subjects who took a larger amount of salt. Itahara and others") have pointed out, that in the north-eastern district, especially in Akita prefecture, of Japan, where the incidence of hypertension and apoplectic attack is significantly high, compared with that in the other districts, the people use to take up an excess of salt in the daily diet. They are at present making effort to improve the diet, restricting the salt intake, and it is now said that the occurrence of those diseases is decreasing, though slightly, year by year. Sapierstein and his collaborators') succeeded in producing a permanent hypertension in rats by administrating hypertonic saline solution every day for a long time. It was reported by Laramore4) and Eichelberger5) that the salt content of the muscles was higher in animals with experimental hypertension.